Protective role of Melissa sp extracte on cardiovascular system and impacts of imidacloprid in Wistar rats

Abstract

Imidacloprid, one of the systemic insecticides and the first compound of the new class of chemical insecticides most used in the world in fields and in horticulture, and Melissa officinalis this medicinal plant known since ancient Greece In this study we are interested in the evaluation on the one hand of the toxicity of this insecticide, and on the other hand the evaluation of the preventive and corrective effect of the extract of Melissa officinal on an animal model; Wistar rats, Our experimentation is divided into four important areas of study, studies of weight changes, studies of oxidative stress parameters, biochemical and metabolic parameters, Our results show that imidacloprid causes a decrease in relative heart weight rats and disturbance in the parameters studied and after the addition of the extract of Melissa officinale we noticed its role and its corrective effect. The present study showed that the exposure to imidacloprid to toxic effects on the parameters mentioned previously, the supplementassions of Melissa officinale improved most of the studied parameters