Etude de l’activité des extraits bioactifs sur des bactéries responsable de l’infection des pieds diabétique

Abstract

Diabetes mellitus, also known as diabetes, is a complex metabolic disorder characterized by hyperglycemia that manifests itself in chronic ways. The WHO estimates that diabetes will be the 7th leading cause of death by 2030. A major complication of diabetes mellitus is foot ulceration (DFU) facilitating the invasion and multiplication of microorganisms resulting in diabetic foot infections (DFI). Which can be defined as an infection involving either soft tissue or bone. DFID can become a chronic disease, often resulting in complications that increase the risk of limb amputation and mortality. Over the years, with an increasing frequency of antibiotic resistant pathogens, and a polymicrobial aspect of IFD, alternative strategies have been proposed, to solve the problem of therapeutic failure, In this perspective we studied the effectiveness of three extracts obtained by maceration (Ethanolic, Methanolic, Acetonic) of three types of propolis: one natural collected from the region of Tebessa and two commercialized (in the form of brown and yellow powder). The study was carried out on solid medium well method. The results revealed a remarkable antiStaphylococcal activity of the different extracts corresponding to the natural propolis and the brown commercialized one. An absence of activity against enterobacteria and pseudomonas Sp was recorded with the three types of propolis. These results make this natural animal source a probable alternative against staphylococcal infections in diabetic foot infections. Key words: DFI, DFU, propolis, propolis extract.