01- بيولوجيا تطبيقية

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    Ameliorative Effects of a Medicinal Plant Against Acetamiprid-Induced Pulmonary Toxicity in Rats
    (Larbi Tebessi University-Tebessa, 2026-06-03) CHABBI, Dhoha; GHEZIL, Zineb; SOUALMIA, Belkis; MESSAADIA, Amira
    Neonicotinoids, particularly acetamiprid (ACE), are widely used insecticides in modern agriculture due to their high efficacy and systemic activity. However, increasing evidence suggests that their high water solubility, rapid absorption, and potential bioaccumulation in biological tissues may lead to adverse health effects in non-target organisms, mainly through oxidative stress and metabolic disruption. In this context, the present study aimed to systematically investigate the toxic effects of ACE exposure on physiological, biochemical, hematological, and oxidative stress parameters in Albino Wistar rats, and to evaluate the potential protective role of green tea extract (GTE) against ACE-induced toxicity. Twenty rats were randomly divided into four groups: a control group receiving standard diet and drinking water, a GTE-treated group receiving 200 mg/kg of green tea extract, an ACE- treated group receiving 20 mg/kg of acetamiprid, and a combined ACE+GTE group receiving acetamiprid followed, three hours later, by green tea extract administration. The treatment was administered orally by gavage for 45 days. The results revealed that ACE exposure induced significant pulmonary and cardiac toxicity, characterized by alterations in hematological and biochemical parameters, including (decreased hemoglobin (HGB), hematocrit (HCT), and mean corpuscular hemoglobin concentration (MCHC), alongside increased in lymphocyte (LY) and lactate dehydrogenase (LDH) activity) levels. Moreover, ACE significantly disrupted the oxidative balance in lung and heart, as evidenced by reduced glutathione (GSH) and an increase in catalase (CAT) levels. In contrast, administration of green tea extract alone showed no toxic effects. Importantly, co- treatment with GTE markedly alleviated ACE-induced alterations across all evaluated parameters, demonstrating a clear protective effect against oxidative stress. Overall, these findings indicate that green tea extract exerts significant antioxidant and protective effects against acetamiprid-induced pulmonary and cardiotoxicity in rats.